People with mental or neurodevelopmental disorders are more likely to show non-right-handedness than those without these conditions, according to a second-order meta-analysis published in Psychological Bulletin.

Handedness—the tendency to prefer one hand over the other—is rooted in our biology and brain organization. Most people are right-handed, but left- and mixed-handed individuals comprise a significant minority. Handedness is shaped by both genetic and environmental factors, and emerges early in development, even prenatally. It is also associated with brain lateralization, especially in regions involved in language. Because some mental and neurodevelopmental disorders are also linked to altered brain asymmetry, researchers have suspected that handedness might reflect underlying neurocognitive differences relevant to these conditions.

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